LS910 - Protein Structural Analysis: Binding Sites to Distant Homologs

Description:

This course covers how to visualize and annotate 3D protein structures using NCBI's Cn3D program, identify conserved domain(s) and ligand binding sites in a protein, search for other proteins containing similar domain(s), explore a 3D modeling template for the query protein and find distant sequence homologs that may not be identified by BLAST.

Objectives:

Topics to be covered include:

• To visualize and annotate 3D rotein structures using Cn3D, a free helper application for your web browser that allows you to view 3-dimensional structures
• To identify the conserved domain(s) present in the query protein and features such as ligand binding sites
• To search for other proteins containing similar domain(s)
• To explore 3D modeling template for the query protein
• To obtain distant sequence homologs that may not be identified by BLAST

Reasonable Accommodations

Individuals who need reasonable accommodation to participate in CIT Training courses should let CIT Training know at least 5 days prior to the class. For interpreting services, please request them from the ORS Interpreting Services by completing the form at Interpreting Services Form or calling (301) 402-8180 or TTY (301) 435-1908 at least 5 days before the start of the class.

Who should attend:

Interested NIH staff

Instructor(s):

Medha Bhagwat, NIH Library

Time Required:

2 Hours

Sections Available: